View source for Di-trans,poly-cis-decaprenylcistransferase

{{enzyme
| Name = N-acetylneuraminate synthase
| EC_number = 2.5.1.56
| CAS_number = 37290-66-7
| IUBMB_EC_number = 2/5/1/56
| GO_code = 0050462
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''N-acetylneuraminate synthase''' ({{EC number|2.5.1.56}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:phosphoenolpyruvate + N-acetyl-D-mannosamine + H<sub>2</sub>O <math>\rightleftharpoons</math> phosphate + N-acetylneuraminate

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[phosphoenolpyruvate]], [[N-acetyl-D-mannosamine]], and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[phosphate]] and [[N-acetylneuraminate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring aryl or alkyl groups other than methyl groups.  The systematic name of this enzyme class is '''phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)'''. Other names in common use include '''(NANA)condensing enzyme''', '''N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)''', and '''NeuAc synthase'''.  This enzyme participates in [[aminosugars metabolism]].

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1WVO}}.

==References==
{{reflist|1}}
* {{cite journal | author = BLACKLOW RS, WARREN L | year = 1962 | title = Biosynthesis of sialic acids by Neisseria meningitidis | journal = J. Biol. Chem.  | volume = 237 | pages = 3520&ndash;6  | pmid = 13971393 }}
* {{cite journal | doi = 10.1271/bbb.61.2046 | author = Komaki E, Ohta Y, Tsukada Y | year = 1997 | title = Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12 | journal = Biosci. Biotechnol. Biochem.  | volume = 61 | pages = 2046&ndash;50  | pmid = 9438985 | issue = 12 }}

[[Category:EC 2.5.1]]
[[Category:Enzymes of known structure]]


{{transferase-stub}}