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{{enzyme
| Name = formylmethanofuran dehydrogenase
| EC_number = 1.2.99.5
| CAS_number = 119940-12-4
| IUBMB_EC_number = 1/2/99/5
| GO_code = 0018493
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''formylmethanofuran dehydrogenase''' ({{EC number|1.2.99.5}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:formylmethanofuran + H<sub>2</sub>O + acceptor <math>\rightleftharpoons</math> CO<sub>2</sub> + methanofuran + reduced acceptor

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[formylmethanofuran]], [[water|H<sub>2</sub>O]], and [[Electron acceptor|acceptor]], whereas its 3 [[product (chemistry)|products]] are [[carbon dioxide|CO<sub>2</sub>]], [[methanofuran]], and [[reduced acceptor]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the aldehyde or oxo group of donor with other acceptors.  The systematic name of this enzyme class is '''formylmethanofuran:acceptor oxidoreductase'''. This enzyme is also called '''formylmethanofuran:(acceptor) oxidoreductase'''.  This enzyme participates in [[folate biosynthesis]].  It has 2 [[cofactor (biochemistry)|cofactors]]: [[molybdenum]],  and [[Pterin]].  

==References==
{{reflist|1}}
* {{cite journal | author = Karrasch M, Borner G, Enssle M, Thauer RK | date = 1990 | title = The molybdoenzyme formylmethanofuran dehydrogenase from Methanosarcina barkeri contains a pterin cofactor | journal = Eur. J. Biochem.  | volume = 194 | pages = 367&ndash;72  | pmid = 2125267 | doi = 10.1111/j.1432-1033.1990.tb15627.x | issue = 2 }}

{{1.2-enzyme-stub}}

[[Category:EC 1.2.99]]
[[Category:Molybdenum enzymes]]
[[Category:Pterin enzymes]]
[[Category:Enzymes of unknown structure]]