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{{enzyme
| Name = 5-(carboxyamino)imidazole ribonucleotide mutase
| EC_number = 5.4.99.18
| CAS_number = 
| IUBMB_EC_number = 5/4/99/18
| GO_code = 
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''5-(carboxyamino)imidazole ribonucleotide mutase''' ({{EC number|5.4.99.18}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole <math>\rightleftharpoons</math> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole]], and one [[product (chemistry)|product]], [[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate]].

This enzyme belongs to the family of [[isomerase]]s, specifically those intramolecular transferases transferring other groups.  The systematic name of this enzyme class is '''5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase'''. Other names in common use include '''N5-CAIR mutase''', '''PurE''', '''N5-carboxyaminoimidazole ribonucleotide mutase''', and '''class I PurE'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM | date = 1992 | title = Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway | journal = Biochemistry.  | volume = 31 | pages = 5022&ndash;32  | pmid = 1534690 | doi = 10.1021/bi00136a016 | issue = 21 }}
* {{cite journal | author = Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J | date = 1994 | title = N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli | journal = Biochemistry.  | volume = 33 | pages = 2269&ndash;78  | pmid = 8117684 | doi = 10.1021/bi00174a038 | issue = 8 }}
* {{cite journal | author = Meyer E, Kappock TJ, Osuji C, Stubbe J | date = 1999 | title = Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase | journal = Biochemistry.  | volume = 38 | pages = 3012&ndash;8  | pmid = 10074353 | doi = 10.1021/bi9827159 | issue = 10 }}
* {{cite journal | author = Mathews II, Kappock TJ, Stubbe J, Ealick SE | date = 1999 | title = Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway | journal = Structure.  | volume = 7 | pages = 1395&ndash;406  | pmid = 10574791 | doi = 10.1016/S0969-2126(00)80029-5 | issue = 11 }}
* {{cite journal | author = Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ | date = 1994 | title = Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms | journal = Biochemistry.  | volume = 33 | pages = 11927&ndash;34  | pmid = 7918411 | doi = 10.1021/bi00205a031 | issue = 39 }}
* {{cite journal | author = Davisson VJ | date = 1998 | title = Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis | journal = Arch. Biochem. Biophys.  | volume = 351 | pages = 123&ndash;34  | pmid = 9500840 | doi = 10.1006/abbi.1997.0512 | last2 = Misialek | first2 = S | last3 = Toffaletti | first3 = DL | last4 = Klem | first4 = TJ | last5 = Perfect | first5 = JR | last6 = Davisson | first6 = VJ | issue = 1 }}

[[Category:EC 5.4.99]]
[[Category:Enzymes of unknown structure]]


{{isomerase-stub}}