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{{enzyme
| Name = adenylyl-sulfate reductase
| EC_number = 1.8.99.2
| CAS_number = 9027-75-2
| IUBMB_EC_number = 1/8/99/2
| GO_code = 0009973
| image = 
| width = 
| caption = 
}}
'''Adenylyl-sulfate reductase''' ({{EC number|1.8.99.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:AMP + sulfite + acceptor <math>\rightleftharpoons</math> adenylyl sulfate + reduced acceptor

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine monophosphate|AMP]], [[sulfite]], and an [[Electron acceptor|acceptor]], whereas its two [[product (chemistry)|products]] are [[adenylyl sulfate]] and a [[reduced acceptor]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on a sulfur group of donors with other acceptors.  The systematic name of this enzyme class is '''AMP,sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)'''. Other names in common use include '''adenosine phosphosulfate reductase''', '''adenosine 5'-phosphosulfate reductase''', '''APS-reductase''', '''APS reductase''', '''AMP, sulfite:(acceptor) oxidoreductase''', and '''(adenosine-5'-phosphosulfate-forming)'''.  This enzyme participates in [[selenoamino acid metabolism]] and [[sulfur metabolism]].  It has 2 [[cofactor (biochemistry)|cofactors]]: [[FAD]],  and [[Iron]].  

==Structural studies==

As of late 2007, 6 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1JNR}}, {{PDB link|1JNZ}}, {{PDB link|2FJA}}, {{PDB link|2FJB}}, {{PDB link|2FJD}}, and {{PDB link|2FJE}}.

==References==
{{reflist|1}}
* {{cite journal | author = Michaels GB, Davidson JT, Peck HD Jr | date = 1970 | title = A flavin-sulfite adduct as an intermediate in the reaction catalyzed by adenylyl sulfate reductase from Desulfovibrio vulgaris | journal = Biochem. Biophys. Res. Commun.  | volume = 39 | pages = 321&ndash;8  | pmid = 5421934 | doi = 10.1016/0006-291X(70)90579-6 | issue = 3 }}

[[Category:EC 1.8.99]]
[[Category:Flavin enzymes]]
[[Category:Iron enzymes]]
[[Category:Enzymes of known structure]]