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{{enzyme
| Name = 5-(carboxyamino)imidazole ribonucleotide synthase
| EC_number = 6.3.4.18
| CAS_number = 
| IUBMB_EC_number = 6/3/4/18
| GO_code = 
| image = 
| width = 
| caption = 
}}

In [[enzymology]], a '''5-(carboxyamino)imidazole ribonucleotide synthase''' ({{EC number|6.3.4.18}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO<sub>3</sub><sup>&minus;</sup> <math>\rightleftharpoons</math> ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[5-amino-1-(5-phospho-D-ribosyl)imidazole]] ("AIR"), and [[bicarbonate|HCO<sub>3</sub><sup>&minus;</sup>]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole]].

This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds.  The systematic name of this enzyme class is '''5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming)'''. Other names in common use include '''N5-CAIR synthetase''', '''N5-carboxyaminoimidazole ribonucleotide synthetase''', and '''PurK'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM | date = 1992 | title = Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway | journal = Biochemistry.  | volume = 31 | pages = 5022&ndash;32  | pmid = 1534690 | doi = 10.1021/bi00136a016 | issue = 21 }}
* {{cite journal | author = Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J | date = 1994 | title = N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli | journal = Biochemistry.  | volume = 33 | pages = 2269&ndash;78  | pmid = 8117684 | doi = 10.1021/bi00174a038 | issue = 8 }}
* {{cite journal | author = Thoden JB, Kappock TJ, Stubbe J, Holden HM | date = 1999 | title = Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily | journal = Biochemistry.  | volume = 38 | pages = 15480&ndash;92  | pmid = 10569930 | doi = 10.1021/bi991618s | issue = 47 }}

[[Category:EC 6.3.4]]
[[Category:Enzymes of unknown structure]]


{{ligase-stub}}