View source for 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase

{{Infobox enzyme
| Name = Cobalt-precorrin-5B (C<sup>1</sup>)-methyltransferase
| EC_number = 2.1.1.195
| CAS_number = 
| IUBMB_EC_number = 2/1/1/195
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Cobalt-precorrin-5B (C<sup>1</sup>)-methyltransferase''' ({{EC number|2.1.1.195}}, ''cobalt-precorrin-6A synthase'', ''CbiD (gene)'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:cobalt-precorrin-5B (C<sup>1</sup>)-methyltransferase''.<ref>{{cite journal | title = The enigma of cobalamin (Vitamin B<sub>12</sub>) biosynthesis in ''Porphyromonas gingivalis''. Identification and characterization of a functional corrin  pathway |author = Roper, J.M., Raux, E., Brindley, A.A., Schubert, H.L., Gharbia, S.E., Shah, H.N. and Warren, M.J. |journal = J. Biol. Chem. |year = 2000 |volume = 275 |pages = 40316–40323 |pmid = 11007789 | doi = 10.1074/jbc.M007146200 | issue = 51}}</ref><ref>{{cite journal | title = Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid ''a'',''c''-diamide, and cobyrinic acid ''a'',''c''-diamide in  ''Escherichia coli'' implies a role for CbiD in C-1 methylation in the  anaerobic pathway to cobalamin |author = Roessner, C.A., Williams, H.J. and Scott, A.I. |journal = J. Biol. Chem. |year = 2005 |volume = 280 |pages = 16748–16753 |pmid = 15741157 | doi = 10.1074/jbc.M501805200 | issue = 17}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[cobalt-precorrin-5B]] + [[S-adenosyl-L-methionine]] <math>\rightleftharpoons</math> [[cobalt-precorrin-6A]] + [[S-adenosyl-L-homocysteine]]

This enzyme catalyses the C-1 [[methylation]] of cobalt-precorrin-5B in the anaerobic pathway of [[adenosylcobalamin]] biosynthesis.

== References ==
{{reflist}}

== External links ==
*{{MeshName|Cobalt-precorrin-5B+(C1)-methyltransferase}}

[[Category:EC 2.1.1]]