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{{Infobox enzyme
| Name = 23S rRNA (guanine<sup>748</sup>-N<sup>1</sup>)-methyltransferase
| EC_number = 2.1.1.188
| CAS_number = 
| IUBMB_EC_number = 2/1/1/188
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA (guanine<sup>748</sup>-N<sup>1</sup>)-methyltransferase''' ({{EC number|2.1.1.188}}, ''Rlma(II)'', ''Rlma2'', ''23S rRNA m1G748 methyltransferase'', ''RlmaII'', ''Rlma II'', ''tylosin-resistance methyltransferase RlmA(II)'', ''TlrB'', ''rRNA large subunit methyltransferase II'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:23S rRNA (guanine<sup>748</sup>-N<sup>1</sup>)-methyltransferase''.<ref>{{cite journal | title = The tylosin-resistance methyltransferase RlmA<sup>II</sup> (TlrB) modifies the ''N''-1 position of 23S rRNA nucleotide G<sup>748</sup> |author = Douthwaite, S., Crain, P.F., Liu, M. and Poehlsgaard, J. |journal = J. Mol. Biol. |year = 2004 |volume = 337 |pages = 1073–1077 |pmid = 15046978}}</ref><ref>{{cite journal | title = The tylosin resistance gene ''tlrB'' of ''Streptomyces fradiae'' encodes a methyltransferase that targets G<sup>748</sup> in 23S rRNA |author = Liu, M., Kirpekar, F., Van Wezel, G.P. and Douthwaite, S. |journal = Mol. Microbiol. |year = 2000 |volume = 37 |pages = 811–820 |pmid = 10972803}}</ref><ref>{{cite journal | title = Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmA<sup>II</sup> |author = Lebars, I., Yoshizawa, S., Stenholm, A.R., Guittet, E., Douthwaite, S. and Fourmy, D. |journal = EMBO J. |year = 2003 |volume = 22 |pages = 183–192 |pmid = 12514124}}</ref><ref>{{cite journal | title = Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA<sup>II</sup> |author = Lebars, I., Husson, C., Yoshizawa, S., Douthwaite, S. and Fourmy, D. |journal = J. Mol. Biol. |year = 2007 |volume = 372 |pages = 525–534 |pmid = 17673230}}</ref><ref>{{cite journal | title = Interaction of the tylosin-resistance methyltransferase RlmA<sup>II</sup> at its rRNA target differs from the orthologue RlmA<sup>I</sup> |author = Douthwaite, S., Jakobsen, L., Yoshizawa, S. and Fourmy, D. |journal = J. Mol. Biol. |year = 2008 |volume = 378 |pages = 969–975 |pmid = 18406425}}</ref><ref>{{cite journal | title = Methylation at nucleotide G<sup>745</sup> or G<sup>748</sup> in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria |author = Liu, M. and Douthwaite, S. |journal = Mol. Microbiol. |year = 2002 |volume = 44 |pages = 195–204 |pmid = 11967079}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[guanine]]<sup>748</sup> in [[Ribosomal RNA|23S rRNA]] <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + N<sup>1</sup>-[[methylguanine]]<sup>748</sup> in 23S rRNA

The enzyme specifically methylates guanine<sup>748</sup> at N<sup>1</sup> in 23S rRNA.

== References ==
{{reflist}}

== External links ==
* {{MeshName|23S+rRNA+(guanine748-N1)-methyltransferase}}

[[Category:EC 2.1.1]]