View source for 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase

{{Infobox enzyme
| Name = 23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>,C<sup>8</sup>)-dimethyltransferase
| EC_number = 2.1.1.194
| CAS_number = 39369-30-7
| IUBMB_EC_number = 2/1/1/194
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>,C<sup>8</sup>)-dimethyltransferase''' ({{EC number|2.1.1.194}}, ''Cfr'', ''Cfr methyltransferase'', ''Cfr rRNA methyltransferase'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:23S rRNA (adenine<sup>2503</sup>-C<sup>2</sup>,C<sup>8</sup>)-dimethyltransferase''.<ref>{{cite journal | title = RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA |author = Yan, F., LaMarre, J.M., RÃ¶hrich, R., Wiesner, J., Jomaa, H., Mankin, A.S., Fujimori, D.G. |journal = J. Am. Chem. Soc. |year = 2010 |volume = 132 |pages = 3953–3964 |pmid = 20184321 | doi = 10.1021/ja910850y | issue = 11 | pmc = 2859901}}</ref><ref>{{cite journal | title = Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in  bacteria |author = Giessing, A.M., Jensen, S.S., Rasmussen, A., Hansen, L.H., Gondela, A., Long, K., Vester, B. and Kirpekar, F. |journal = RNA |year = 2009 |volume = 15 |pages = 327–336 |pmid = 19144912 | doi = 10.1261/rna.1371409 | issue = 2 | pmc = 2648713}}</ref><ref>{{cite journal | title = Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria |author = Kaminska, K.H., Purta, E., Hansen, L.H., Bujnicki, J.M., Vester, B. and Long, K.S. |journal = Nucleic Acids Res. |year = 2010 |volume = 38 |pages = 1652–1663 |pmid = 20007606 | doi = 10.1093/nar/gkp1142 | issue = 5 | pmc = 2836569}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 2 [[S-adenosyl-L-methionine]] + [[adenine]]<sup>2503</sup> in [[Ribosomal RNA|23S rRNA]] <math>\rightleftharpoons</math> 2 [[S-adenosyl-L-homocysteine]] + [[2,8-dimethyladenine]]<sup>2503</sup> in 23S rRNA

This enzyme contains an [4Fe-S] cluster.

== References ==
{{reflist}}

== External links ==
*{{MeshName|23S+rRNA+(adenine2503-C2,C8)-dimethyltransferase}}

[[Category:EC 2.1.1]]