View source for 12-oxophytodienoate reductase

{{enzyme
| Name = 2-coumarate reductase
| EC_number = 1.3.1.11
| CAS_number = 37251-10-8
| IUBMB_EC_number = 1/3/1/11
| GO_code = 0047788
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''2-coumarate reductase''' ({{EC number|1.3.1.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3-(2-hydroxyphenyl)propanoate + NAD<sup>+</sup> <math>\rightleftharpoons</math> 2-coumarate + NADH + H<sup>+</sup>

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3-(2-hydroxyphenyl)propanoate]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[2-coumarate]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor.  The systematic name of this enzyme class is '''3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase'''. This enzyme is also called '''melilotate dehydrogenase'''.  This enzyme participates in [[phenylalanine metabolism]].

== References ==
{{reflist|1}}
* {{cite journal | author = Levy CC and Weinstein GD | year = 1964 | title = The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid | journal = Biochemistry  | volume = 3 | issue = 12 | pages = 1944&ndash;1947 | doi = 10.1021/bi00900a027 | pmid=14269315}}

[[Category:EC 1.3.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]
[[Category:Hydroxycinnamic acids metabolism]]

{{1.3-enzyme-stub}}