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{{enzyme
| Name = 3-hydroxyisobutyryl-CoA hydrolase
| EC_number = 3.1.2.4
| CAS_number = 9025-88-1
| IUBMB_EC_number = 3/1/2/4
| GO_code = 0003860
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''3-hydroxyisobutyryl-CoA hydrolase''' ({{EC number|3.1.2.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3-hydroxy-2-methylpropanoyl-CoA + H<sub>2</sub>O <math>\rightleftharpoons</math> CoA + 3-hydroxy-2-methylpropanoate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3-hydroxy-2-methylpropanoyl-CoA]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[coenzyme A|CoA]] and [[3-hydroxy-2-methylpropanoate]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on [[thioester]] bonds.  The systematic name of this enzyme class is '''3-hydroxy-2-methylpropanoyl-CoA hydrolase'''. Other names in common use include '''3-hydroxy-isobutyryl CoA hydrolase''', and '''HIB CoA deacylase'''.  This enzyme participates in 3 [[metabolism|metabolic pathways]]: [[valine, leucine and isoleucine degradation]], [[beta-alanine metabolism]], and [[propanoate metabolism]].

==References==
{{reflist|1}}
* {{cite journal | author = Rendina G and Coon MJ | year = 1957 | title = Enzymatic hydrolysis of the coenzyme A thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids | journal = J. Biol. Chem.  | volume = 225 | issue = 1 | pages = 523&ndash;534 | pmid=13457352}}

[[Category:EC 3.1.2]]
[[Category:Enzymes of unknown structure]]


{{hydrolase-stub}}