View source for 1-Deoxypentalenic acid 11beta-hydroxylase

{{Infobox enzyme
| Name = Pentachlorophenol monooxygenase
| EC_number = 1.14.13.50
| CAS_number = 136111-57-4
| IUBMB_EC_number = 1/14/13/50
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Pentachlorophenol monooxygenase''' ({{EC number|1.14.13.50}}, ''pentachlorophenol dechlorinase'', ''pentachlorophenol dehalogenase'', ''pentachlorophenol 4-monooxygenase'', ''PCP hydroxylase'', ''pentachlorophenol hydroxylase'', ''PcpB'', ''PCB 4-monooxygenase'', ''PCB4MO'') is an [[enzyme]] with system name ''pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)''.<ref>{{cite journal | title = Enzymatic dehalogenation of pentachlorophenol by extracts from <em>Arthrobacter sp</em>. strain ATCC 33790 |author = Schenk, T., M&uuml;ller, R., M&ouml;rsberger, F., Otto, M.K. and Lingens, F. |journal = J. Bacteriol. |year = 1989 |volume = 171 |pages = 5487–5491 |pmid = 2793827 |issue=10 |pmc=210388}}</ref><ref>{{cite journal | title = Diverse substrate range of a <em>Flavobacterium</em> pentachlorophenol hydroxylase and reaction stoichiometries |author = Xun, L., Topp, E. and Orser, C.S. |journal = J. Bacteriol. |year = 1992 |volume = 174 |pages = 2898–2902 |pmid = 1569020 |issue=9 |pmc=205942}}</ref><ref>{{cite journal | title = Confirmation of oxidative dehalogenation of pentachlorophenol by a <em>Flavobacterium</em> pentachlorophenol hydroxylase |author = Xun, L., Topp, E. and Orser, C.S. |journal = J. Bacteriol. |year = 1992 |volume = 174 |pages = 5745–5747 |pmid = 1512208 |issue=17 |pmc=206524}}</ref><ref>{{cite journal | title = Verification of the role of PCP 4-monooxygenase in chlorine elimination from pentachlorophenol by <em>Flavobacterium</em> sp. strain ATCC 39723 |author = Lange, C.C., Schneider, B.J. and Orser, C.S. |journal = Biochem. Biophys. Res. Commun. |year = 1996 |volume = 219 |pages = 146–149 |pmid = 8619798 |doi=10.1006/bbrc.1996.0196 |issue=1}}</ref><ref>{{cite journal | title = Identification, characterization, and site-directed mutagenesis of recombinant pentachlorophenol 4-monooxygenase |author = Nakamura, T., Motoyama, T., Hirono, S. and Yamaguchi, I. |journal = Biochim. Biophys. Acta |year = 2004 |volume = 1700 |pages = 151–159 |pmid = 15262224 |doi=10.1016/j.bbapap.2004.04.008 |issue=2}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) [[pentachlorophenol]] + 2 NADPH + H<sup>+</sup> + O</sub>2 <math>\rightleftharpoons</math> 2,3,5,6-tetrachlorohydroquinone + 2 NADP<sup>+</sup> + [[chloride]] + H<sub>2</sub>O
: (2) 2,3,5,6-tetrachlorophenol + NADPH + H<sup>+</sup> + O2 <math>\rightleftharpoons</math> 2,3,5,6-tetrachlorohydroquinone + NADP<sup>+</sup> + H<sub>2</sub>O

Pentachlorophenol monooxygenase is a flavoprotein (FAD). 

== References ==
{{reflist}}

== External links ==
* {{MeshName|Pentachlorophenol+monooxygenase}}

[[Category:EC 1.14.13]]