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{{enzyme
| Name = 2-alkenal reductase
| EC_number = 1.3.1.74
| CAS_number = 9032-20-6
| IUBMB_EC_number = 1/3/1/74
| GO_code = 0032440
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''2-alkenal reductase''' ({{EC number|1.3.1.74}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:n-alkanal + NAD(P)+ <math>\rightleftharpoons</math> alk-2-enal + NAD(P)H + H<sup>+</sup>

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[n-alkanal]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[alk-2-enal]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor.  The systematic name of this enzyme class is '''n-alkanal:NAD(P)+ 2-oxidoreductase'''. Other names in common use include '''NAD(P)H-dependent alkenal/one oxidoreductase''', and '''NADPH:2-alkenal alpha,beta-hydrogenase'''.  

==Structural studies==

As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2DM6}}, {{PDB link|2J3J}}, and {{PDB link|2J3K}}.

==References==
{{reflist|1}}
* {{cite journal | author = D, Babiychuk E, Kushnir S, Asada K | date = 2002 | title = The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes | journal = Plant. Cell. Physiol.  | volume = 43 | pages = 1445&ndash;55  | pmid = 12514241 | doi = 10.1093/pcp/pcf187 | issue = 12 }}
* {{cite journal | author = Dick RA, Kwak MK, Sutter TR, Kensler TW | date = 2001 | title = Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase | journal = J. Biol. Chem.  | volume = 276 | pages = 40803&ndash;10  | pmid = 11524419 | doi = 10.1074/jbc.M105487200 | issue = 44 }}

{{1.3-enzyme-stub}}

[[Category:EC 1.3.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of known structure]]