View source for (citrate (pro-3S)-lyase) ligase

{{enzyme
| Name = dicarboxylate-CoA ligase
| EC_number = 6.2.1.23
| CAS_number = 99332-77-1
| IUBMB_EC_number = 6/2/1/23
| GO_code = 0047851
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''dicarboxylate-CoA ligase''' ({{EC number|6.2.1.23}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + an alphaomega-dicarboxylic acid + CoA <math>\rightleftharpoons</math> AMP + diphosphate + an omega-carboxyacyl-CoA

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[alphaomega-dicarboxylic acid]], and [[coenzyme A|CoA]], whereas its 3 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], and [[omega-carboxyacyl-CoA]].

This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-sulfur bonds as acid-thiol ligases.  The systematic name of this enzyme class is '''omega-dicarboxylate:CoA ligase (AMP-forming)'''. Other names in common use include '''carboxylyl-CoA synthetase''', and '''dicarboxylyl-CoA synthetase'''.

==References==
{{reflist|1}}
* {{cite journal | author = Vamecq J, de Hoffmann E, Van Hoof F | year = 1985 | title = The microsomal dicarboxylyl-CoA synthetase | journal = Biochem. J.  | volume = 230 | pages = 683&ndash;93  | pmid = 4062873 | issue = 3 | pmc = 1152672 }}

{{DEFAULTSORT:Dicarboxylate-CoA ligase}}
[[Category:EC 6.2.1]]
[[Category:Enzymes of unknown structure]]


{{ligase-stub}}