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{{enzyme
| Name = tetrahydrocolumbamine 2-O-methyltransferase
| EC_number = 2.1.1.89
| CAS_number = 93792-09-7
| IUBMB_EC_number = 2/1/1/89
| GO_code = 0030762
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''tetrahydrocolumbamine 2-O-methyltransferase''' ({{EC number|2.1.1.89}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + tetrahydropalmatine

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[S-Adenosyl methionine|S-adenosyl methionine]] and [[5,8,13,13a-tetrahydrocolumbamine]], whereas its two [[product (chemistry)|products]] are [[S-adenosylhomocysteine]] and [[tetrahydropalmatine]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring one-carbon group methyltransferases.  The systematic name of this enzyme class is '''S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase'''. This enzyme is also called '''tetrahydrocolumbamine methyltransferase'''.  This enzyme participates in [[alkaloid biosynthesis i]].  

==References==
{{reflist|1}}
* {{cite journal | author = Beecher CWW and Kelleher WJ | date = 1984 | title = Enzymatic study of the late stages of protoberberine alkaloid biosynthesis | journal = Tetrahedron Lett.  | volume = 25 | pages = 4595&ndash;4598 | doi = 10.1016/S0040-4039(01)91208-0 | issue = 41 }}

{{transferase-stub}}

[[Category:EC 2.1.1]]
[[Category:Enzymes of unknown structure]]