View source for (Myelin basic protein)-arginine N-methyltransferase

{{enzyme
| Name = phosphatidyl-N-methylethanolamine N-methyltransferase
| EC_number = 2.1.1.71
| CAS_number = 67167-73-1
| IUBMB_EC_number = 2/1/1/71
| GO_code = 0000773
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''phosphatidyl-N-methylethanolamine N-methyltransferase''' ({{EC number|2.1.1.71}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[S-Adenosyl methionine|S-adenosyl methionine]] and [[phosphatidyl-N-methylethanolamine]], whereas its two [[product (chemistry)|products]] are [[S-adenosylhomocysteine]] and [[phosphatidyl-N-dimethylethanolamine]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring one-carbon group methyltransferases.  The systematic name of this enzyme class is '''S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase'''. Other names in common use include '''phosphatidylmonomethylethanolamine methyltransferase''', '''methyltransferase II''', '''phospholipid methyltransferase''', '''PLMT''', '''phosphatidyl-N-methylethanolamine methyltransferase''', '''phosphatidyl-N-monomethylethanolamine methyltransferase''', '''phosphatidylethanolamine methyltransferase I''', and '''phosphatidylmonomethylethanolamine methyltransferase'''.  This enzyme participates in [[glycine]], [[serine]] and [[threonine]] [[metabolism]] and [[glycerophospholipid]] [[metabolism]].  

==References==
{{reflist|1}}
* {{cite journal | author = Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J | date = 1978 | title = Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 75 | pages = 1718&ndash;21  | pmid = 25437 | doi = 10.1073/pnas.75.4.1718 | issue = 4 | pmc = 392410 }}
* {{cite journal | author = Schneider WJ, Vance DE | date = 1979 | title = Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities | journal = J. Biol. Chem.  | volume = 254 | pages = 3886&ndash;91  | pmid = 438165 | issue = 10 }}

[[Category:EC 2.1.1]]
[[Category:Enzymes of unknown structure]]


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