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{{Infobox enzyme
| Name = UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase
| EC_number = 1.1.1.335
| CAS_number = 
| IUBMB_EC_number = 1/1/1/335
| GO_code = 
| image = 
| width = 
| caption =
}}
'''UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase''' ({{EC number|1.1.1.335}}, ''WlbA'', ''WbpB'') is an [[enzyme]] with system name ''UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD<sup>+</sup> 3-oxidoreductase''.<ref>{{cite journal | title = Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-<small>D</small>-mannuronic acid in <em>Pseudomonas aeruginosa</em> |author = Westman, E.L., McNally, D.J., Charchoglyan, A., Brewer, D., Field, R.A. and Lam, J.S. |journal = J. Biol. Chem. |year = 2009 |volume = 284 |pages = 11854–11862 |pmid = 19282284 |doi=10.1074/jbc.M808583200 |pmc=2673254}}</ref><ref>{{cite journal | title = Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in <em>Pseudomonas aeruginosa</em> PAO1 |author = Larkin, A. and Imperiali, B. |journal = Biochemistry |year = 2009 |volume = 48 |pages = 5446–5455 |pmid = 19348502 |doi=10.1021/bi900186u |pmc=2694220}}</ref><ref>{{cite journal | title = Structural and functional studies of WlbA: A dehydrogenase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-<small>D</small>-mannuronic acid |author = Thoden, J.B. and Holden, H.M. |journal = Biochemistry |year = 2010 |volume = 49 |pages = 7939–7948 |pmid = 20690587 |doi=10.1021/bi101103s |issue=36}}</ref><ref>{{cite journal | title = Biochemical and structural characterization of WlbA from <em>Bordetella pertussis</em> and <em>Chromobacterium violaceum</em>: enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-<small>D</small>-mannuronic acid |author = Thoden, J.B. and Holden, H.M. |journal = Biochemistry |year = 2011 |volume = 50 |pages = 1483–1491 |pmid = 21241053 |doi=10.1021/bi101871f |issue=9 |pmc=3050068}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD<sup>+</sup> <math>\rightleftharpoons</math> UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH + H<sup>+</sup>

This enzyme participates in the biosynthesis of [[lipopolysaccharide]] UDP-alpha-D-ManNAc3NAcA.

== References ==
{{reflist}}

== External links ==
* {{MeshName|UDP-N-acetyl-2-amino-2-deoxyglucuronate+dehydrogenase}}

[[Category:EC 1.1.1]]