View source for (R)-2-haloacid dehalogenase

{{enzyme
| Name = 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
| EC_number = 4.1.2.21
| CAS_number = 9030-99-3
| IUBMB_EC_number = 4/1/2/21
| GO_code = 0008674
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''2-dehydro-3-deoxy-6-phosphogalactonate aldolase''' ({{EC number|4.1.2.21}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:2-dehydro-3-deoxy-D-galactonate 6-phosphate <math>\rightleftharpoons</math> pyruvate + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[2-dehydro-3-deoxy-D-galactonate 6-phosphate]], and two [[product (chemistry)|products]], [[pyruvate]] and [[D-glyceraldehyde 3-phosphate]].

This enzyme belongs to the family of [[lyase]]s, specifically the aldehyde-lyases, which cleave carbon-carbon bonds.  The systematic name of this enzyme class is '''2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)'''. Other names in common use include '''6-phospho-2-keto-3-deoxygalactonate aldolase''', '''phospho-2-keto-3-deoxygalactonate aldolase''', '''2-keto-3-deoxy-6-phosphogalactonic aldolase''', '''phospho-2-keto-3-deoxygalactonic aldolase''', '''2-keto-3-deoxy-6-phosphogalactonic acid aldolase''', '''(KDPGal)aldolase''', '''2-dehydro-3-deoxy-D-galactonate-6-phosphate''', and '''D-glyceraldehyde-3-phosphate-lyase'''.  This enzyme participates in [[galactose metabolism]].  

==Structural studies==

As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2V81}} and {{PDB link|2V82}}.

==References==
{{reflist|1}}
* {{cite journal | author = Shuster CW | date = 1966 | title = 2-Keto-3-deoxy-6-phosphogalactonic acid aldolase | journal = Methods Enzymol.  | volume = 9 | pages = 524&ndash;528 | doi = 10.1016/0076-6879(66)09104-3 | chapter = [92] 2-Keto-3-deoxy-6-phosphogalactonic acid aldolase | series = Methods in Enzymology | isbn = 978-0-12-181809-8 }}

{{4.1-enzyme-stub}}

[[Category:EC 4.1.2]]
[[Category:Enzymes of known structure]]