Born equation

2014-01-13T23:36:10Z

77.251.113.33: r_0, consistent with explanation of parameters.

{{DISPLAYTITLE:3-hydroxypropionate dehydrogenase (NADP+)}}
{{Infobox enzyme
| Name = 3-hydroxypropionate dehydrogenase (NADP+)
| EC_number = 1.1.1.298
| CAS_number =
| IUBMB_EC_number = 1/1/1/298
| GO_code =
| image =
| width =
| caption =
}}
'''3-hydroxypropionate dehydrogenase (NADP+)''' ({{EC number|1.1.1.298}}) is an [[enzyme]] with system name ''3-hydroxypropionate:NADP+ oxidoreductase''.<ref>{{cite journal | title = Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium ''Chloroflexus aurantiacus'', the 3-hydroxypropionate cycle |author = Strauss, G. and Fuchs, G. |journal = Eur. J. Biochem. |year = 1993 |volume = 215 |pages = 633–643 |pmid = 8354269 |doi=10.1111/j.1432-1033.1993.tb18074.x}}</ref><ref>{{cite journal | title = A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea |author = Berg, I. A., Kockelkorn, D., Buckel, W. and Fuchs, G. |journal = Science |year = 2007 |volume = 318 |pages = 1782–1786 |pmid = 18079405 |doi=10.1126/science.1149976}}</ref><ref>{{cite journal | title = Malonyl-coenzyme A reductase from ''Chloroflexus aurantiacus'', a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation |author = Hugler, M., Menendez, C., Schagger, H. and Fuchs, G. |journal = J. Bacteriol. |year = 2002 |volume = 184 |pages = 2404–2410 |pmid = 11948153 |issue=9 |pmc=134993}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 3-hydroxypropionate + NADP+ <math>\rightleftharpoons</math> malonate semialdehyde + NADPH + H+

This enzyme catalyses the reduction of malonate semialdehyde to 3-hydroxypropionate, which is a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively. The enzyme from ''[[Chloroflexus aurantiacus]]'' is bifunctional, and also catalyses the upstream reaction in the pathway, [[EC 1.2.1.75]]. Different from [[EC 1.1.1.59]], 3-hydroxypropionate dehydrogenase (NAD+), by cofactor preference.

== References ==
{{reflist}}

== External links ==
* {{MeshName|3-hydroxypropionate+dehydrogenase+(NADP+)}}

[[Category:EC 1.1.1]]

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Born equation